CRP Turbi

After tissue damage or inflammation, liver synthesized C-Reactive Protein is one of the most sensitive acute phase reactants. CRP tests are used for the detection of systemic inflammatory processes, evaluation of antibiotic treatment of bacterial infections, detection of intrauterine infections with concomitant premature amniorexia, distinguishing between active and inactive forms of diseases that are also infectious, detection of the presence of post-operative complications such as infected wounds, thrombosis and pneumonia at an early stage and distinguishing between infection and bone marrow transplant rejection. Postoperative monitoring of patients’ CRP levels can help the detection of unexpected complications (constantly high or increasing levels). Measuring the changes in CRP concentration provides useful diagnostic information about how acute and how serious a disease is. It also allows making decisions about the occurrence of the disease. A persistent high serum CRP concentration is a serious prognostic sign, often indicating the presence of an uncontrollable infection. The level of CRP in plasma increases dramatically after atherosclerosis, stress, trauma, infection, inflammation, surgery, or neoplastic proliferation. The increase occurs within 24 to 48 hours and the level is 2000 times normal. All tissue-related damage is expected to increase, but the finding is nonspecific. Serum C-reactive protein causes precipitation of latex particles coated with anti-human C-reactive protein. The precipitation of latex particles is directly proportional to the CRP concentration and can be measured turbidimetrically. Clinical diagnosis should not be made only with the findings of test results; integration of the laboratory data should be used in clinical diagnosis as well.